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- $Unique_ID{BRK03514}
- $Pretitle{}
- $Title{Barrett Syndrome}
- $Subject{Barrett Syndrome Barrett Ulcer Barrett Esophagus Chronic Peptic Ulcer
- and Esophagitis Syndrome Columnar-Like Esophagus Esophagitis-Peptic Ulcer}
- $Volume{}
- $Log{}
-
- Copyright (C) 1986 National Organization for Rare Disorders, Inc.
-
- 173:
- Barrett Syndrome
-
- ** IMPORTANT **
- It is possible the main title of the article (Barrett Syndrome) is not
- the name you expected. Please check the SYNONYM listing to find alternate
- names and disorder subdivisions covered by this article.
-
- Synonyms
-
- Barrett Ulcer
- Barrett Esophagus
- Chronic Peptic Ulcer and Esophagitis Syndrome
- Columnar-Like Esophagus
- Esophagitis-Peptic Ulcer
-
- General Discussion
-
- ** REMINDER **
- The information contained in the Rare Disease Database is provided for
- educational purposes only. It should not be used for diagnostic or treatment
- purposes. If you wish to obtain more information about this disorder, please
- contact your personal physician and/or the agencies listed in the "Resources"
- section of this report.
-
-
- Barrett Syndrome is a rare disorder caused by a chronic peptic ulcer of
- the esophagus. It is characterized by heartburn and recurrent pain behind
- the sternum. Eventually large ulcers or narrowing of the esophagus
- (stricture) may occur.
-
- Symptoms
-
- Barrett Syndrome generally occurs in middle aged or elderly people. The
- symptoms of the disorder may be present for weeks or years. Recurrent low
- pain in the upper middle region of the abdomen behind the sternum, heartburn,
- and belching are characteristic of the disease. The pain may radiate to the
- neck, scapular region, or both arms. This may be especially noticeable after
- eating acidic, hot or cold food, or while lying down. Later in the course of
- the disease, there may be difficulty in swallowing (dysphagia), vomiting, or
- regurgitation. Sometimes melena (blackened vomit or stools) or hematemesis
- (vomiting of blood) may occur. There may also be loss of weight.
-
- Causes
-
- Barrett Syndrome may occur as a result of a chronic peptic ulcer of the
- esophagus. The lining of the esophagus is destroyed by reflux esophagitis
- (reflux of the acid and pepsin from the stomach) resulting in inflammation.
- The ulcer may penetrate or perforate the esophagus, and bleed. The disorder
- is usually associated with a hiatal hernia. Barrett Syndrome is sometimes
- congenital.
-
- Affected Population
-
- Barrett Syndrome usually occurs in middle aged and elderly persons and
- affects men and women equally.
-
- Therapies: Standard
-
- Medical therapy includes elevating the head of the bed, avoiding bedtime
- snacks or liquids, Urecholine, metoclopramide, cimetidine and antacids.
- Treatment of Barrett Syndrome may require surgery to remove the ulceration if
- medicines have not been effective. Since cancer of the esophagus is more
- common in Barrett Syndrome, frequent checkups are essential.
-
- Therapies: Investigational
-
- This disease entry is based upon medical information available through
- December 1988. Since NORD's resources are limited, it is not possible to
- keep every entry in the Rare Disease Database completely current and
- accurate. Please check with the agencies listed in the Resources section for
- the most current information about this disorder.
-
- Resources
-
- For more information on Barrett Syndrome, please contact:
-
- National Organization for Rare Disorders (NORD)
- P.O. Box 8923
- New Fairfield, CT 06812-1783
- (203) 746-6518
-
- National Digestive Diseases Information Clearinghouse
- Box NDIC
- Bethesda, MD 20892
- (301) 468-2162
-
- References
-
- THE MERCK MANUAL 15th ed: R. Berkow, et al: eds; Merck, Sharp & Dohme
- Research Laboratories, 1987. P. 719.
-
- MENDELIAN INHERITANCE IN MAN, 8th ed.: Victor A. McKusick; Johns Hopkins
- University Press, 1986. P. 90.
-
-